The transcription factor dFOXO controls the expression of insulin pathway genes and lipids content under heat stress in <i>Drosophila melanogaster</i>

The insulin/insulin-like growth factor signaling (IIS) pathway is one of the key elements in an organism’s response to unfavourable conditions. deep homology this and its evolutionary conservative role controlling carbohydrate lipid metabolism make it possible use Drosophila melanogaster for studying functioning. To identify properties interaction two IIS components under heat stress D. (the forkhead box O transcription (dFOXO) insulin-like peptide 6 (DILP6), which intermediates dFOXO signal sent from fat body insulin-producing cells brain where DILPs1–5 are synthesized), we analysed expression genes dilp6 , dfoxo receptor gene ( dInR ) females strains carrying hypomorphic mutation 41 hypofunctional foxo BG01018 . We found that neither influenced uprise short-term stress, but both them disrupted genes. reveal identified disruptions control feeding behaviour, effect mutations on total lipids content capillary intensity imago normal conditions stress. Both caused increase these parameters prevented decrease following observed strain. In mutants, was increased conditions; decreased all studied first 24 h observation, strain, 48 h. Thus, may conclude takes part regulating as well changes by regulation mediated DILP6. At same time, behaviour might be controlled DILP6 conditions, not